The game was decided before most of the crowd at Fenway Park had settled into their seats. Baltimore scored four runs in the first inning, and Boston never found a way back, falling 5-1 to the Orioles.

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Eduardo Rivera lasted just 0.2 innings, charged with 4 runs on 3 hits and 2 walks in the decisive first. Pete Alonso scored on a wild pitch, Dylan Beavers followed with a two-run single, and Rodríguez doubled home another run, all in the same frame. Beavers finished 2-for-4 with 2 RBIs, and Gunnar Henderson crossed the plate twice, going 1-for-3 with a triple and a walk.

Boston's only run came in the fourth, when Yoshida singled to left and Contreras scored. Contreras went 1-for-2 with a double. Baltimore tacked on a seventh-inning run when Henderson scored on a wild pitch from Morán, pushing the score to 5-1.

Brayan Bello held the Orioles scoreless in relief of the disastrous start, working 5.1 innings with 5 strikeouts and 0 runs allowed on 4 hits, a performance that stood in stark contrast to the first-inning collapse. Boston's bullpen as a whole covered 8.1 innings and allowed just 1 run, but the early deficit was already too much to overcome. Kyle Bradish worked 6.0 innings for Baltimore, allowing 1 run on 4 hits with 4 strikeouts to secure the win, improving to 7-9 with a 3.49 ERA. Bradish sits at 489 career strikeouts, 11 shy of the 500 mark.

Baltimore improved to 50-53, snapping back with a win after dropping its previous game. Boston fell to 52-49, having lost its previous game as well.