Joe Ryan reached 50 career wins on June 1, 2026, as the Minnesota Twins defeated the Chicago White Sox 9-6 at Target Field. The milestone victory came in Ryan's sixth major league season since debuting in 2021.

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Across his MLB career as a whole, Ryan has appeared in 128 games with a 50-39 record, 798 strikeouts, and a 3.73 ERA over 711.7 innings pitched. The right-hander has compiled these numbers entirely with the Twins organization, appearing in 5 games in 2021, 27 in 2022, 29 in 2023, 23 in 2024, and 31 in 2025.

The victory improved Ryan's 2026 record to 3-3 through 12 starts. He has struck out 70 batters in 64.3 innings this season while maintaining a 2.94 ERA and 0.93 WHIP.

The 50-win milestone marks six seasons of major league service with the Minnesota organization. Ryan reached the mark in his sixth season since debuting in 2021.